Structure of PDB 8oeq Chain AY

Receptor sequence

>8oeqAY (length=361) Species: 5476 (Candida albicans) [Search protein sequence]

SRPQVSVISVKGEQGSSQLPLPAVFAAPVRPDLVHSVFVRVNKNKRQAYA
VAENAGHQTSAESWGTGRAVARIPRVGGGGTHRSGQAAFGNMCRGGRMFA
PTKTWRRWNVKVNHNEKRYATASAIAASAVTSLVLARGHRVEQVKELPLV
VSNEFESVTKTKDAVAVLKAVGAHKDVVKVIKSKKLRAGKGKLRGRRFTQ
RRGPLVVYAQDNGIVKALRNVPGVETASVKHLGLLQLAPGAHLGRFIIWT
QGAFESLDSVYGSDSTKSIKSGYTLPSNIISNTDVTRLINSAEVQAVVRP
AGEKTQKKSHVLKKNPLKNKQVLLRLNPYAKAYAAEKVGSAKVEQAKVKP
SKGQFAEVLKN

3D structure

PDB

8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AY	R32 L35 H37 R42 N44 K45 N46 K47 R48 Q49 Y51 V53 A54 A57 G58 H59 Q60 T61 S62 T68 G69 A71 V72 R74 P76 G79 G81 G82 T83 H84 R85 Q88 A89 N93 M94 C95 R96 G97 R99 M100 F101 A102 P103 K105 W107 R108 R109 V112 K113 N115 H116 N117 E118 K119 R120 R139 G140 R142 K162 T163 K164 K181 K184 S185 K187 L188 R189 A190 G191 K192 R196 R198 R203 R204 Y210 K218 R221 N222 T228 A229 H233 L234 G235 G242 H244 K272 S273 T288 N292 Q297 R301 A303 G304 E305 T307 Q308 K309 K310 S311 V313 L314 K316 N321 Q323 L326 R327 A332 Y335 A336 G341 S342 A343 K344 V345 Q347 V350 K351 P352 S353 L361	R30 L33 H35 R40 N42 K43 N44 K45 R46 Q47 Y49 V51 A52 A55 G56 H57 Q58 T59 S60 T66 G67 A69 V70 R72 P74 G77 G79 G80 T81 H82 R83 Q86 A87 N91 M92 C93 R94 G95 R97 M98 F99 A100 P101 K103 W105 R106 R107 V110 K111 N113 H114 N115 E116 K117 R118 R137 G138 R140 K160 T161 K162 K179 K182 S183 K185 L186 R187 A188 G189 K190 R194 R196 R201 R202 Y208 K216 R219 N220 T226 A227 H231 L232 G233 G240 H242 K270 S271 T286 N290 Q295 R299 A301 G302 E303 T305 Q306 K307 K308 S309 V311 L312 K314 N319 Q321 L324 R325 A330 Y333 A334 G339 S340 A341 K342 V343 Q345 V348 K349 P350 S351 L359
BS02	rna	AY	A50 A52 A54 K194 L195	A48 A50 A52 K192 L193

External links

PDB	RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum	8oeq
PubMed
UniProt	A0A8H6F4H4

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