Structure of PDB 4v6n Chain AY

Receptor sequence

>4v6nAY (length=84) Species: 562 (Escherichia coli)

AHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANV
GCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE

3D structure

• PDB: 4v6n Structural characterization of mRNA-tRNA translocation intermediates.
• Chain: AY
• Resolution: 12.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AY	V70 K71 G72 P73 N75	V70 K71 G72 P73 N75
BS02	rna	AY	H2 K3 G7 S8 T9 R10 N11 G12 R13 D14 S15 E16 K18 R19 L20 V22 K23 R24 F25 V30 S34 R38 Q39 R40 G41 T42 G51 G53 R54 D55 H56 F59 K61 F68	H2 K3 G7 S8 T9 R10 N11 G12 R13 D14 S15 E16 K18 R19 L20 V22 K23 R24 F25 V30 S34 R38 Q39 R40 G41 T42 G51 G53 R54 D55 H56 F59 K61 F68
BS03	rna	AY	A1 H2 K4	A1 H2 K4
BS04	rna	AY	H2 K3 K4 A5	H2 K3 K4 A5

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0043022 ribosome binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0001558 regulation of cell growth
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042256 cytosolic ribosome assembly
• GO:0090070 positive regulation of ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v6n, PDBe:4v6n, PDBj:4v6n
• PDBsum: 4v6n
• PubMed: 22467828
• UniProt: P0A7L8|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)