Structure of PDB 5aj0 Chain AX

Receptor sequence

>5aj0AX (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]

KIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMK
KIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYV
RLAPDYDALDVANKIGI

3D structure

PDB

5aj0 Structural Snapshots of Actively Translating Human Ribosomes

Chain

Resolution

3.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AX	T51 R62 K63 R67 R68 N69 K70 Q108	T13 R24 K25 R29 R30 N31 K32 Q70
BS02	rna	AX	P44 T45 F46 R47 R48 T51 L52 R53 R56 Y60 T83 S85 K89 N93 N105 K106 H107 K123 T126 L127 I128 P130 K134 K135 Y137 R139	P6 T7 F8 R9 R10 T13 L14 R15 R18 Y22 T45 S47 K51 N55 N67 K68 H69 K85 T88 L89 I90 P92 K96 K97 Y99 R101

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0045296	cadherin binding
GO:1904841	TORC2 complex binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:5aj0, PDBe:5aj0, PDBj:5aj0
PDBsum	5aj0
PubMed	25957688
UniProt	P62750\|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)