Structure of PDB 6olg Chain AT

Receptor sequence

>6olgAT (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEF

3D structure

PDB

6olg Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AT	R20 L27 A28	R19 L26 A27
BS02	rna	AT	T2 N3 T4 K5 G6 K7 R8 R9 R12 Y13 M14 S16 H22 G23 D41 K43 G46 T47 Q49 K50 H54 K55 Y57 H58 T61 T68 Q69 H70 K81 K87 R88 R92 F105 V109 K116 W125 L128 K129 R130 P132 F140 R142	T1 N2 T3 K4 G5 K6 R7 R8 R11 Y12 M13 S15 H21 G22 D40 K42 G45 T46 Q48 K49 H53 K54 Y56 H57 T60 T67 Q68 H69 K80 K86 R87 R91 F104 V108 K115 W124 L127 K128 R129 P131 F139 R141

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6olg, PDBe:6olg, PDBj:6olg
PDBsum	6olg
PubMed	31160784
UniProt	P46778\|RL21_HUMAN Large ribosomal subunit protein eL21 (Gene Name=RPL21)

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