Structure of PDB 5aj0 Chain AT

Receptor sequence

>5aj0AT (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEF

3D structure

PDB

5aj0 Structural Snapshots of Actively Translating Human Ribosomes

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AT	R20 P26 A28	R19 P25 A27
BS02	rna	AT	T2 N3 T4 K5 G6 K7 R8 R9 R12 Y13 M14 R17 H22 G23 K35 D41 G46 T47 Q49 K50 H54 K55 Y57 H58 G59 K60 T61 T68 Q69 H70 A71 K81 K87 R88 N90 K100 S101 F105 V109 Q127 K129 R130 Q131 P132 F140 R142	T1 N2 T3 K4 G5 K6 R7 R8 R11 Y12 M13 R16 H21 G22 K34 D40 G45 T46 Q48 K49 H53 K54 Y56 H57 G58 K59 T60 T67 Q68 H69 A70 K80 K86 R87 N89 K99 S100 F104 V108 Q126 K128 R129 Q130 P131 F139 R141

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5aj0, PDBe:5aj0, PDBj:5aj0
PDBsum	5aj0
PubMed	25957688
UniProt	P46778\|RL21_HUMAN Large ribosomal subunit protein eL21 (Gene Name=RPL21)

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