Structure of PDB 7toq Chain AS18

Receptor sequence

>7toqAS18 (length=144) Species: 9986 (Oryctolagus cuniculus)

SLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADID
LTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLAN
GLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT

3D structure

• PDB: 7toq Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
• Chain: AS18
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AS18	R24 K25 F28 G35 V36 G37 R38 R39 Y40 R55 W82 F83 N85 R86 Q87 K88 H120 R121 R124 H125 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 R141 R142 R144 T145	R23 K24 F27 G34 V35 G36 R37 R38 Y39 R54 W81 F82 N84 R85 Q86 K87 H119 R120 R123 H124 L128 R129 V130 R131 G132 Q133 H134 T135 K136 T137 T138 R140 R141 R143 T144

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7toq, PDBe:7toq, PDBj:7toq
• PDBsum: 7toq
• PubMed: 35589706
• UniProt: G1TPG3|RS18_RABIT Small ribosomal subunit protein uS13 (Gene Name=RPS18)