Structure of PDB 7toq Chain AS03

Receptor sequence
>7toqAS03 (length=228) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIII
LATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIA
QAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSM
KFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPSGKIGP
KKPLPDHVSIVEPKDEILPTTPISEQKG
3D structure
PDB7toq Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
ChainAS03
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna AS03 V3 Q4 I5 S6 K7 R9 K141 Q145 R146 K151 L156 M157 I158 H159 S160 G161 D162 P163 H174 Q179 V181 K185 P205 D206 V3 Q4 I5 S6 K7 R9 K141 Q145 R146 K151 L156 M157 I158 H159 S160 G161 D162 P163 H174 Q179 V181 K185 P205 D206
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0016829 lyase activity
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006412 translation
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0031334 positive regulation of protein-containing complex assembly
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051301 cell division
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005819 spindle
GO:0005840 ribosome
GO:0005856 cytoskeleton
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7toq, PDBe:7toq, PDBj:7toq
PDBsum7toq
PubMed35589706
UniProtG1TNM3|RS3_RABIT Small ribosomal subunit protein uS3 (Gene Name=RPS3)

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