Structure of PDB 8ppl Chain AS

Receptor sequence

>8pplAS (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]

SLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADID
LTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLAN
GLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTV

3D structure

PDB

8ppl Universal features of Nsp1-mediated translational shutdown by coronaviruses.

Chain

Resolution

2.65 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	AS	R24 K25 F28 G35 V36 G37 R38 R39 Y40 R55 W82 F83 N85 Q87 K88 L107 D110 H120 R121 R124 H125 L129 R130 V131 R132 Q134 H135 T136 K137 T138 T139 R141 R142 R144 T145 V146	R23 K24 F27 G34 V35 G36 R37 R38 Y39 R54 W81 F82 N84 Q86 K87 L106 D109 H119 R120 R123 H124 L128 R129 V130 R131 Q133 H134 T135 K136 T137 T138 R140 R141 R143 T144 V145
BS02	MG	AS	T136 T139	T135 T138
BS03	MG	AS	T31 I33 V36	T30 I32 V35

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8ppl, PDBe:8ppl, PDBj:8ppl
PDBsum	8ppl
PubMed	37802027
UniProt	P62269\|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)