Structure of PDB 6olg Chain AS

Receptor sequence

>6olgAS (length=175) Species: 9606 (Homo sapiens)

MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQ
LKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDL
TTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKI
KFPLPHRVLRRQHKPRFTTKRPNTF

3D structure

• PDB: 6olg Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
• Chain: AS
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AS	S42 Y46 S49 K53 K55 S57 R120 H122	S42 Y46 S49 K53 K55 S57 R120 H122
BS02	rna	AS	K2 S4 G5 R8 Y63 V67 F68 P72 R74 S86 R87 S88 M93 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 P155 H156 R157 V158 R160 Q162 H163 R166 T168 T169 K170 R171 P172 N173 T174	K2 S4 G5 R8 Y63 V67 F68 P72 R74 S86 R87 S88 M93 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 P155 H156 R157 V158 R160 Q162 H163 R166 T168 T169 K170 R171 P172 N173 T174

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6olg, PDBe:6olg, PDBj:6olg
• PDBsum: 6olg
• PubMed: 31160784
• UniProt: Q02543|RL18A_HUMAN Large ribosomal subunit protein eL20 (Gene Name=RPL18A)