Structure of PDB 3jbp Chain AR

Receptor sequence

>3jbpAR (length=252) Species: 36329 (Plasmodium falciparum 3D7)

KVVKNKAYFKRYQVKYRRRREGKTDYRARKALILQDKNKYNAQKLRFVVR
KTNSQVICQIACAHIEGDKILAEAKSKELIRYGIPVGLKNYAAAYATGLL
CARRFLKSLNLDTQFLGVEKVTRKPIKAFLDVGITRTTTGNRVFAALKGA
CDGGLNIPHGNNRFPGSFNPEQLRKNILGIHVAEYMKTLQEEDNDKYKTH
FNDYLKNNIGADDIEQMYLNAHEKIRQNPKKLNAKLRKKRVKEKLALYVE
LQ

3D structure

• PDB: 3jbp Dynamical features of the Plasmodium falciparum ribosome during translation.
• Chain: AR
• Resolution: 6.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AR	K5 V6 K8 Y12 R15 Y16 K19 R23 G26 T28 R31 K43 K48 R141 I144 F147 I152 R154 T155 H177 G178 R181	K1 V2 K4 Y8 R11 Y12 K15 R19 G22 T24 R27 K39 K44 R123 I126 F129 I134 R136 T137 H159 G160 R163
BS02	rna	AR	K10 F13 K14 Y20 R21 R22 R24 K27 T28 Y30 R33 R50 R54 K55 T56 N57 S58 Q59 Q63 E70 G71 D72 K73 I74 K79 K81 K93 N94 Y95 T153 R154 N159 R160 Y206 H221 F222 N223 D224 Y225 K271 K272 L273 A275 R278 R281 V282 K285	K6 F9 K10 Y16 R17 R18 R20 K23 T24 Y26 R29 R46 R50 K51 T52 N53 S54 Q55 Q59 E66 G67 D68 K69 I70 K75 K77 K89 N90 Y91 T135 R136 N141 R142 Y185 H200 F201 N202 D203 Y204 K230 K231 L232 A234 R237 R240 V241 K244

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:3jbp, PDBe:3jbp, PDBj:3jbp
• PDBsum: 3jbp
• PubMed: 26432834
• UniProt: Q8ILL3