Structure of PDB 7zrz Chain AP1

Receptor sequence
>7zrzAP1 (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
MLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPL
LLMPEEARLLAEIGAVTLVSAPRPLDWRVQSKDWPHAGRPAHELRYSIYR
DLWERGFFLSAAGKFGGDFLVYPGDPLRFFAHYIAQCWAPEDTIPLQDLV
AAGRLGTSVRKTLLLCSPQPDGKVVYTSLQWASL
3D structure
PDB7zrz Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN.
ChainAP1
Resolution3.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.16: tRNA-intron lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna AP1 R41 S44 K239 Y247 F255 R285 R41 S44 K114 Y122 F130 R160
Gene Ontology
Molecular Function
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
Biological Process
GO:0000379 tRNA-type intron splice site recognition and cleavage
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
Cellular Component
GO:0000214 tRNA-intron endonuclease complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zrz, PDBe:7zrz, PDBj:7zrz
PDBsum7zrz
PubMed37231152
UniProtQ9BSV6|SEN34_HUMAN tRNA-splicing endonuclease subunit Sen34 (Gene Name=TSEN34)

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