Structure of PDB 6xzd Chain AP1

Receptor sequence

>6xzdAP1 (length=696) Species: 100673 (Influenza C virus (C/Johannesburg/1/66))

SKTFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCDE
YLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEKQ
FVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQKL
RIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLELRDESVPL
PFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIRL
PKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRPK
DKPLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGIGRASKKIP
EISLTQDVITTEGLKQSENKLPEPRSFPRWFNAEWMWAIKDSDLTGWVPM
AEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECRL
FPGKIKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHLNKDDGM
YTIITFEFSIREPNLEKHQKYTVFEAGHTTVREVPLYLYCRTTALSKIKN
DWLSKARRCFITTMDTVETICLRESAKAEENLVEKTLNEKQMWIGKKNGE
LIAQPLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKILMALEGDKKNKS
SFGFNPEGLLEKIEECLINNPMCLFMAQRLNELVIEASKRGAKFFK

3D structure

• PDB: 6xzd Host ANP32A mediates the assembly of the influenza virus replicase.
• Chain: AP1
• Resolution: 3.4 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AP1	G342 I343 R345 P373 R450 H494 M501 K558	G341 I342 R344 P372 R449 H493 M500 K547

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6xzd, PDBe:6xzd, PDBj:6xzd
• PDBsum: 6xzd
• PubMed: 33208942
• UniProt: Q9IMP5|PA_INCJH Polymerase acidic protein (Gene Name=PA)