Structure of PDB 6olz Chain AP

Receptor sequence

>6olzAP (length=153) Species: 9606 (Homo sapiens) [Search protein sequence]

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT
EKE

3D structure

PDB

6olz Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AP	R3 S5 R30 R61 R62 W78 N120 K121 P123	R2 S4 R29 R60 R61 W77 N119 K120 P122
BS02	rna	AP	R3 Y4 K16 R18 S20 H25 K27 N28 R30 K37 Q54 R62 Y63 N64 G65 G66 G68 R69 Q72 K74 Q75 Q80 R82 W83 K85 K86 H93 S100 N101 H116 Q118 V119 K121 K124 M125 R127 T129 Y130 R131 A132 H133 G134 N137 P138 Y139 M140	R2 Y3 K15 R17 S19 H24 K26 N27 R29 K36 Q53 R61 Y62 N63 G64 G65 G67 R68 Q71 K73 Q74 Q79 R81 W82 K84 K85 H92 S99 N100 H115 Q117 V118 K120 K123 M124 R126 T128 Y129 R130 A131 H132 G133 N136 P137 Y138 M139

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0015934	large ribosomal subunit

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6olz, PDBe:6olz, PDBj:6olz
PDBsum	6olz
PubMed	31160784
UniProt	P18621\|RL17_HUMAN Large ribosomal subunit protein uL22 (Gene Name=RPL17)

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