Structure of PDB 5xth Chain AP

Receptor sequence
>5xthAP (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
SHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYA
AKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRH
RTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANA
GDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG
3D structure
PDB5xth Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
ChainAP
Resolution3.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H239
Catalytic site (residue number reindexed from 1) H161
Enzyme Commision number 7.1.1.8: quinol--cytochrome-c reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FES AP C217 H219 L220 C222 C236 H239 C139 H141 L142 C144 C158 H161
BS02 PLX AP Y115 T118 V125 Y37 T40 V47
Gene Ontology
Molecular Function
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0051537 2 iron, 2 sulfur cluster binding
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5xth, PDBe:5xth, PDBj:5xth
PDBsum5xth
PubMed28844695
UniProtP47985|UCRI_HUMAN Cytochrome b-c1 complex subunit Rieske, mitochondrial (Gene Name=UQCRFS1)

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