Structure of PDB 7mpj Chain AN

Receptor sequence

>7mpjAN (length=203) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

GAYKYLEELQRKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRL
GYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRAT
AEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWI
CDPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWR
YRK

3D structure

PDB

7mpj CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	AN	G2 Y4 K5 E8 R12 K14 Q15 R24 W28 R31 N34 V35 R41 R44 K47 R49 R50 L51 K54 A55 K56 Q57 R67 R68 G69 N70 R71 K72 R73 P74 P76 K77 G78 Y81 G82 K83 P84 T85 N86 Q87 V89 N90 E91 K93 Y94 Q95 R96 S97 L98 R105 R108 N112 N117 S125 Y127 K128 Q138 H139 K140 A141 R144 R147 W150 P154 V155 H156 K157 H158 R159 R162 A166 K169 K170 S171 R172 I174 K176 G177 H178 K179 F180 N181 R187 R188 K189 W191 K192 R193 Q194 S198 W200 R201 Y202 R203 K204	G1 Y3 K4 E7 R11 K13 Q14 R23 W27 R30 N33 V34 R40 R43 K46 R48 R49 L50 K53 A54 K55 Q56 R66 R67 G68 N69 R70 K71 R72 P73 P75 K76 G77 Y80 G81 K82 P83 T84 N85 Q86 V88 N89 E90 K92 Y93 Q94 R95 S96 L97 R104 R107 N111 N116 S124 Y126 K127 Q137 H138 K139 A140 R143 R146 W149 P153 V154 H155 K156 H157 R158 R161 A165 K168 K169 S170 R171 I173 K175 G176 H177 K178 F179 N180 R186 R187 K188 W190 K191 R192 Q193 S197 W199 R200 Y201 R202 K203
BS02	rna	AN	R38 Q57 V60 Y62 R109 N112 D136 H139	R37 Q56 V59 Y61 R108 N111 D135 H138
BS03	MG	AN	G88 V89 N90	G87 V88 N89
BS04	MG	AN	R188 K189	R187 K188
BS05	MG	AN	W200 R201 Y202	W199 R200 Y201
BS06	MG	AN	R172 G186	R171 G185
BS07	MG	AN	R50 G52	R49 G51

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7mpj, PDBe:7mpj, PDBj:7mpj
PDBsum	7mpj
PubMed	35489333
UniProt	P05748\|RL15A_YEAST Large ribosomal subunit protein eL15A (Gene Name=RPL15A)

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