Structure of PDB 7tor Chain AL34

Receptor sequence

>7torAL34 (length=114) Species: 9986 (Oryctolagus cuniculus)

VQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPG
RLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQK
IVVKVLKAQAQSQK

3D structure

• PDB: 7tor Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
• Chain: AL34
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL34	V2 R4 T6 Y7 R8 R9 R10 L11 S12 Y13 N14 T15 R24 T25 P26 N28 R29 Y32 Y34 K36 K37 K40 P42 K43 A45 V48 P50 G51 R54 G55 R57 A58 R60 P61 K62 L64 M65 R66 S68 K69 T70 K72 H73 V74 S75 R76 Y78 G79 G80 S81 R90 R93 A94 I97 E98 K101	V1 R3 T5 Y6 R7 R8 R9 L10 S11 Y12 N13 T14 R23 T24 P25 N27 R28 Y31 Y33 K35 K36 K39 P41 K42 A44 V47 P49 G50 R53 G54 R56 A57 R59 P60 K61 L63 M64 R65 S67 K68 T69 K71 H72 V73 S74 R75 Y77 G78 G79 S80 R89 R92 A93 I96 E97 K100
BS02	ZN	AL34	C46 C49 C86	C45 C48 C85

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7tor, PDBe:7tor, PDBj:7tor
• PDBsum: 7tor
• PubMed: 35589706
• UniProt: G1TXG5|RL34_RABIT Large ribosomal subunit protein eL34 (Gene Name=RPL34)