Structure of PDB 7tor Chain AL21

Receptor sequence

>7torAL21 (length=159) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEFMA

3D structure

PDB

7tor Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

AL21

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL21	T2 N3 T4 K5 G6 K7 R8 R9 G10 R12 Y13 M14 S16 R17 F19 H22 G23 K35 D41 K43 G46 T47 Q49 K50 G51 H54 Y57 H58 G59 K60 T61 T68 Q69 H70 N77 K78 V80 K81 K87 R88 I89 N90 R92 K100 S101 R102 S104 F105 R108 V109 K110 W125 L128 K129 R130 F140 R142	T1 N2 T3 K4 G5 K6 R7 R8 G9 R11 Y12 M13 S15 R16 F18 H21 G22 K34 D40 K42 G45 T46 Q48 K49 G50 H53 Y56 H57 G58 K59 T60 T67 Q68 H69 N76 K77 V79 K80 K86 R87 I88 N89 R91 K99 S100 R101 S103 F104 R107 V108 K109 W124 L127 K128 R129 F139 R141
BS02	rna	AL21	R20 P26 L27 A28	R19 P25 L26 A27

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7tor, PDBe:7tor, PDBj:7tor
PDBsum	7tor
PubMed	35589706
UniProt	G1SHQ2\|RL21_RABIT Large ribosomal subunit protein eL21 (Gene Name=RPL21)

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