Structure of PDB 7too Chain AL21

Receptor sequence

>7tooAL21 (length=159) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

GKSHGYRSRTRYMFQRDFRKHGAVHLSTYLKVYKVGDIVDIKANGSIQKG
MPHKFYQGKTGVVYNVTKSSVGVIINKMVGNRYLEKRLNLRVEHIKHSKC
RQEFLERVKANAAKRAEAKAQGVAVQLKRQPAQPRESRIVSTEGNVPQTL
APVPYETFI

3D structure

PDB

7too Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

AL21

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL21	G2 K3 S4 H5 G6 Y7 R8 S9 R10 R12 Y13 M14 Q16 R17 F19 G23 K43 G46 S47 Q49 K50 H54 K55 F56 Y57 Q58 G59 T61 T68 K69 S70 S71 K78 V80 R83 L85 K87 R88 K100 C101 E104 F105 R108 V109 N112 R116 Q127 L128 K129 R130	G1 K2 S3 H4 G5 Y6 R7 S8 R9 R11 Y12 M13 Q15 R16 F18 G22 K42 G45 S46 Q48 K49 H53 K54 F55 Y56 Q57 G58 T60 T67 K68 S69 S70 K77 V79 R82 L84 K86 R87 K99 C100 E103 F104 R107 V108 N111 R115 Q126 L127 K128 R129
BS02	rna	AL21	R20 H26 S28	R19 H25 S27

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7too, PDBe:7too, PDBj:7too
PDBsum	7too
PubMed	35589706
UniProt	Q02753\|RL21A_YEAST Large ribosomal subunit protein eL21A (Gene Name=RPL21A)

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