Structure of PDB 7too Chain AL20

Receptor sequence

>7tooAL20 (length=172) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

MAHFKEYQVIGRRLPTESVPEPKLFRMRIFASNEVIAKSRYWYFLQKLHK
VKKASGEIVSINQINEAHPTKVKNFGVWVRYDSRSGTHNMYKEIRDVSRV
AAVETLYQDMAARHRARFRSIHILKVAEIEKTADVKRQYVKQFLTKDLKF
PLPHRVQKSTKTFSYKRPSTFY

3D structure

PDB

7too Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

AL20

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL20	M1 A2 N62 N65 H68 P69 K71 R84 M90 Y91 Q108 A111 A112 R113 H114 R115 R117 T132 R137 Y139 L144 H154 Q157 K158 S159 K161 Y165 S169 T170 F171	M1 A2 N62 N65 H68 P69 K71 R84 M90 Y91 Q108 A111 A112 R113 H114 R115 R117 T132 R137 Y139 L144 H154 Q157 K158 S159 K161 Y165 S169 T170 F171
BS02	rna	AL20	S39 Y43 Q46 H49 K50 V51 K52 R119	S39 Y43 Q46 H49 K50 V51 K52 R119

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7too, PDBe:7too, PDBj:7too
PDBsum	7too
PubMed	35589706
UniProt	P0CX23\|RL20A_YEAST Large ribosomal subunit protein eL20A (Gene Name=RPL20A)

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