Structure of PDB 7toq Chain AL17

Receptor sequence

>7toqAL17 (length=153) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT
EKE

3D structure

PDB

7toq Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

AL17

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL17	V2 R3 Y4 L6 K16 R18 G19 S20 R23 H25 F26 K27 N28 R30 Q34 K37 K54 R62 Y63 N64 G65 G66 G68 R69 A71 Q72 K74 Q75 W78 T79 Q80 R82 W83 P84 K85 K86 H93 N97 S100 N101 H116 I117 Q118 V119 K121 R127 T129 Y130 R131 A132 H133 G134 R135 I136 N137 P138 Y139 M140 S141	V1 R2 Y3 L5 K15 R17 G18 S19 R22 H24 F25 K26 N27 R29 Q33 K36 K53 R61 Y62 N63 G64 G65 G67 R68 A70 Q71 K73 Q74 W77 T78 Q79 R81 W82 P83 K84 K85 H92 N96 S99 N100 H115 I116 Q117 V118 K120 R126 T128 Y129 R130 A131 H132 G133 R134 I135 N136 P137 Y138 M139 S140
BS02	rna	AL17	R3 S5 R61 R62 W78 N120 K121 P123	R2 S4 R60 R61 W77 N119 K120 P122

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0015934	large ribosomal subunit

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7toq, PDBe:7toq, PDBj:7toq
PDBsum	7toq
PubMed	35589706
UniProt	G1SCJ6\|RL17_RABIT Large ribosomal subunit protein uL22 (Gene Name=RPL17)

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