Structure of PDB 7top Chain AL13

Receptor sequence

>7topAL13 (length=193) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

AISKNLPILKNHFRKHWQERVKVHFDQAGKKVSRRNARATRAAKIAPRPL
DLLRPVVRAPTVKYNRKVRAGRGFTLAEVKAAGLTAAYARTIGIAVDHRR
QNRNQEIFDANVQRLKEYQSKIIVFPRNGKAPEAEQVLSAAATFPIAQPA
TDVEARAVQDNGESAFRTLRLARSEKKFRGIREKRAREKAEAE

3D structure

PDB

7top Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

AL13

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL13	I3 S4 K5 L7 L10 K11 N12 H13 F14 R15 K16 H17 W18 Q19 K23 Q28 A29 K31 K32 R35 R36 R39 R42 R55 V58 R59 P61 V63 Y65 N66 K68 R70 R73 K81 R91 D98 H99 R100 R101 R104 R168 R171 R174 K178 F179 R180 G181 R183 K185 R186	I2 S3 K4 L6 L9 K10 N11 H12 F13 R14 K15 H16 W17 Q18 K22 Q27 A28 K30 K31 R34 R35 R38 R41 R54 V57 R58 P60 V62 Y64 N65 K67 R69 R72 K80 R90 D97 H98 R99 R100 R103 R167 R170 R173 K177 F178 R179 G180 R182 K184 R185
BS02	rna	AL13	F26 D27 K31	F25 D26 K30

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7top, PDBe:7top, PDBj:7top
PDBsum	7top
PubMed	35589706
UniProt	Q12690\|RL13A_YEAST Large ribosomal subunit protein eL13A (Gene Name=RPL13A)

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