Structure of PDB 7top Chain AL09

Receptor sequence

>7topAL09 (length=191) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNN
QLIKVAVHNGGRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPIN
VNIVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNS
VEDVSQNAADLQQICRVRNKDIRKFLDGIYVSHKGFITEDL

3D structure

PDB

7top Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Chain

AL09

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL09	M1 S19 I20 K21 S22 R23 I24 K26 H40 D42 V43 T44 V57 H58 R62 K63 A66 R69 T70 S73 L74 N77 H96 F97 D120 K121 K122 S155 Q156 Q163 R168 K170 D171 R173 K174 K184	M1 S19 I20 K21 S22 R23 I24 K26 H40 D42 V43 T44 V57 H58 R62 K63 A66 R69 T70 S73 L74 N77 H96 F97 D120 K121 K122 S155 Q156 Q163 R168 K170 D171 R173 K174 K184

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7top, PDBe:7top, PDBj:7top
PDBsum	7top
PubMed	35589706
UniProt	P05738\|RL9A_YEAST Large ribosomal subunit protein uL6A (Gene Name=RPL9A)

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