Structure of PDB 4v9r Chain AL

Receptor sequence

>4v9rAL (length=122) Species: 274 (Thermus thermophilus)

PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPK

3D structure

• PDB: 4v9r The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
• Chain: AL
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AL	P5 T6 N8 Q9 R12 R15 E16 S22 A30 P31 F32 R33 R34 K47 N49 S50 L52 R53 K54 T61 Y69 G72 E73 R86 G87 V90 K91 D92 R97 R113 K114 K115 S116 R117 S118 K119 Y120 T122 K123 K124	P1 T2 N4 Q5 R8 R11 E12 S18 A26 P27 F28 R29 R30 K43 N45 S46 L48 R49 K50 T57 Y65 G68 E69 R82 G83 V86 K87 D88 R93 R109 K110 K111 S112 R113 S114 K115 Y116 T118 K119 K120
BS02	peptide	AL	R34 V36 R59 H80 V82	R30 V32 R55 H76 V78
BS03	MG	AL	P48 N49	P44 N45

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v9r, PDBe:4v9r, PDBj:4v9r
• PDBsum: 4v9r
• PubMed: 24412368
• UniProt: Q5SHN3|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)