Structure of PDB 4woi Chain AK

Receptor sequence

>4woiAK (length=117) Species: 83333 (Escherichia coli K-12)

RKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFA
AQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITD
VTPIPHNGCRPPKKRRV

3D structure

• PDB: 4woi Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.
• Chain: AK
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AK	H22 N28 N29 I31 T33 G39 N40 A41 W44 A47 G48 G49 R53 G54 S55 K87 P115 I116 H118 N119 G120 C121 R122 P124 K125 K126 R127 R128	H10 N16 N17 I19 T21 G27 N28 A29 W32 A35 G36 G37 R41 G42 S43 K75 P103 I104 H106 N107 G108 C109 R110 P112 K113 K114 R115 R116
BS02	rna	AK	S50 R69 D72 K75 E76	S38 R57 D60 K63 E64
BS03	rna	AK	K14 Q15 V16	K2 Q3 V4

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0070181 small ribosomal subunit rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4woi, PDBe:4woi, PDBj:4woi
• PDBsum: 4woi
• PubMed: 26224058
• UniProt: P0A7R9|RS11_ECOLI Small ribosomal subunit protein uS11 (Gene Name=rpsK)