Structure of PDB 7mpi Chain AJ

Receptor sequence

>7mpiAJ (length=169) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

QNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVR
TFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRDRNFSATGNFGFG
IDEHIDLGIKYDPSIGIFGMDFYVVMNRPGARVTRRKRCKGTVGNSHKTT
KEDTVSWFKQKYDADVLDK

3D structure

PDB

7mpi CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.

Chain

Resolution

3.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AJ	K16 V18 N20 S22 S48 K49 A50 R51 Y52 F57 I59 H68 R92 R94 N95 F96 S97 T99 N101 G103 F104 G105 G124 D126 Y128 V130 K142 K153	K11 V13 N15 S17 S43 K44 A45 R46 Y47 F52 I54 H63 R87 R89 N90 F91 S92 T94 N96 G98 F99 G100 G119 D121 Y123 V125 K137 K148
BS02	rna	AJ	N7 M9 R10 Q43 T44 V46 H68 V69 T70 R72 G135 R137 R141 R143 G149 N150 H152	N2 M4 R5 Q38 T39 V41 H63 V64 T65 R67 G130 R132 R136 R138 G144 N145 H147

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7mpi, PDBe:7mpi, PDBj:7mpi
PDBsum	7mpi
PubMed	35489333
UniProt	P0C0W9\|RL11A_YEAST Large ribosomal subunit protein uL5A (Gene Name=RPL11A)

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