Structure of PDB 6olz Chain AJ

Receptor sequence

>6olzAJ (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]

ENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVR
SFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFG
IQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRIS
KEEAMRWFQQKYDGIILPG

3D structure

PDB

6olz Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	AJ	M12 R16 Q46 T47 C72 T73 R75 G138 I141 D143 K144 R147 I151 A153 K154	M4 R8 Q38 T39 C64 T65 R67 G130 I133 D135 K136 R139 I143 A145 K146
BS02	rna	AJ	K19 C21 N23 C25 S51 A53 F60 N98 D101 T102 N104 F107 G127 L128 D129 Y131 K145	K11 C13 N15 C17 S43 A45 F52 N90 D93 T94 N96 F99 G119 L120 D121 Y123 K137
BS03	rna	AJ	T56 R58 R64	T48 R50 R56

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006605	protein targeting
GO:0010628	positive regulation of gene expression
GO:0032092	positive regulation of protein binding
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6olz, PDBe:6olz, PDBj:6olz
PDBsum	6olz
PubMed	31160784
UniProt	P62913\|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)

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