Structure of PDB 5aj0 Chain AJ

Receptor sequence

>5aj0AJ (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]

ENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVR
SFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFG
IQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRIS
KEEAMRWFQQKYDGIILPG

3D structure

PDB

5aj0 Structural Snapshots of Actively Translating Human Ribosomes

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	AJ	M12 R16 Q46 T47 V49 T73 R75 P137 G138 S140 I141 D143 K144 K145 R147 G152 K154 H155	M4 R8 Q38 T39 V41 T65 R67 P129 G130 S132 I133 D135 K136 K137 R139 G144 K146 H147
BS02	rna	AJ	K19 C21 N23 C25 G27 S51 A53 R54 V57 F60 I62 N97 N98 S100 D101 T102 N104 G106 F107 Q110 G127 D129 Y131 K145	K11 C13 N15 C17 G19 S43 A45 R46 V49 F52 I54 N89 N90 S92 D93 T94 N96 G98 F99 Q102 G119 D121 Y123 K137
BS03	rna	AJ	T56 R58 R64	T48 R50 R56

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006605	protein targeting
GO:0010628	positive regulation of gene expression
GO:0032092	positive regulation of protein binding
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5aj0, PDBe:5aj0, PDBj:5aj0
PDBsum	5aj0
PubMed	25957688
UniProt	P62913\|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)

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