Structure of PDB 5tbw Chain AG

Receptor sequence

>5tbwAG (length=106) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

AESHRLYVKGKHLSYQRSKRVNNPNVSLIKIEGVATPQDAQFYLGKRIAY
VYRASKEVRGSKIRVMWGKVTRTHGNSGVVRATFRNNLPAKTFGASVRIF
LYPSNI

3D structure

PDB

5tbw Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.

Chain

Resolution

3.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AG	A2 E3 S4 H5 R6 Y8 R18 S19 K20 R21 V22 N23 Q42 L45 Y53 R54 S56 K57 R60 S62 I64 R65 V66 M67 W68 K70 R73 H75 G76 N77 S78 R82 R86 N88 P90 A91 K92 F94 A96 S97 R99	A1 E2 S3 H4 R5 Y7 R17 S18 K19 R20 V21 N22 Q41 L44 Y52 R53 S55 K56 R59 S61 I63 R64 V65 M66 W67 K69 R72 H74 G75 N76 S77 R81 R85 N87 P89 A90 K91 F93 A95 S96 R98
BS02	OHX	AG	F85 R86	F84 R85

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:5tbw, PDBe:5tbw, PDBj:5tbw
PDBsum	5tbw
PubMed	29064494
UniProt	P05744\|RL33A_YEAST Large ribosomal subunit protein eL33A (Gene Name=RPL33A)