Structure of PDB 4w2f Chain AG

Receptor sequence

>4w2fAG (length=155) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQ
EKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLAL
RWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAY
AHYRW

3D structure

PDB

4w2f Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AG	A2 R3 R4 R6 A7 R10 N28 K29 I30 M31 R32 D33 G34 K35 K36 R41 R76 R79 R94 R95 S98 R102 N109 R114 R115 A116 R119	A1 R2 R3 R5 A6 R9 N27 K28 I29 M30 R31 D32 G33 K34 K35 R40 R75 R78 R93 R94 S97 R101 N108 R113 R114 A115 R118
BS02	rna	AG	S77 Q86 D140 R143 M144 A147	S76 Q85 D139 R142 M143 A146

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0000028	ribosomal small subunit assembly
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4w2f, PDBe:4w2f, PDBj:4w2f
PDBsum	4w2f
PubMed	25306919
UniProt	P17291\|RS7_THET8 Small ribosomal subunit protein uS7 (Gene Name=rpsG)

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