Structure of PDB 6gaz Chain AE

Receptor sequence

>6gazAE (length=343) Species: 9823 (Sus scrofa)

SFFTKLTADELWKGALAESGAGARKGRGKRTKKKRRKDLNRGQIIGEGRH
GFLWPGLNIPLMRNGAVQTIAQRSKEDQEKVEADMVQQREEWDRRRKMKV
KRERGWSGNTWGGVSLGPPDPGPNGETYDDFDTRILEVRNVFNMTAKEGR
KRSVRVLVAVGNGKGAAGFAIGKATERADAFRKAKNRAVHYLHYIERYED
HTIYHDISLKFKRTHIKMKKQPRGYGLHCHRAIMTICRLIGIKDLYAKVS
GSVNMLNLTRGLFLGLSRQETHQQLADKKSLHVVEFREECGPLPIVVASP
QGALRKDPEPEDEVPDITLDWEDVKAAQGMKRSVWSGLKRAAT

3D structure

• PDB: 6gaz Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM.
• Chain: AE
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AE	T91 K100 G101 A104 G109 R114 K116 T118 K119 R191 S194 G195 N196 R226 V228 F229 N230 M231 T232 A233 K234 R237 R242 I258 K260 R269 R274 K299 R300 H315 C316 H317 R318 Y333 K335 V336 S339 N341 R347 W408 R419 S420 V421 W422 R427	T4 K13 G14 A17 G22 R27 K29 T31 K32 R104 S107 G108 N109 R139 V141 F142 N143 M144 T145 A146 K147 R150 R155 I171 K173 R182 R187 K212 R213 H228 C229 H230 R231 Y246 K248 V249 S252 N254 R260 W321 R332 S333 V334 W335 R340
BS02	rna	AE	K112 G113 R117 R122 R128 R182 F229 R237	K25 G26 R30 R35 R41 R95 F142 R150

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6gaz, PDBe:6gaz, PDBj:6gaz
• PDBsum: 6gaz
• PubMed: 30089917
• UniProt: F1SU66