Structure of PDB 8b6f Chain AD

Receptor sequence
>8b6fAD (length=441) Species: 312017 (Tetrahymena thermophila SB210) [Search protein sequence]
SYGNLKDQDRIFTNLYRDGDPFVKGALKRGDWHQTKEILSNGPEWIIDEI
KKSGLRGRGGAGFLSGLKYSFMPKVNPDGRPSYLVINSDESEPGTCKDRE
ILRNDPHKLVEGALVVGFSMRARAAYIYIRGEFWVEANILQQAIDEAYAK
GFIGKNACGSGYDFDVYIHRGAGAYICGEETGLIESIEGKAGQPRVKPPF
PANAGLYGCPTTVTNVETVAVCPTIMRRGASWFASFGRPNNAGTKLYCIS
GHVNNPCTVEEEMSIPLRELLEKHCGGVRGGWDNLLAVIPGGSSVPMMPK
NVCDDVLMDFDALKAVGSGLGTAAVIVMDKSTDPIDAILRLSKFYKHESC
GQCTPCREGTGWIVDVMERLLVGNADYAEIDMLQQVTQQIEMHTICALGD
AAAWPVQGLIKNFREEIEDRIDSYHAKHPQLKKSRKSNPQI
3D structure
PDB8b6f Structural basis of mitochondrial membrane bending by the I-II-III 2 -IV 2 supercomplex.
ChainAD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 AD I206 P224 C380 G381 Q382 C383 C386 C426 L428 I176 P194 C350 G351 Q352 C353 C356 C396 L398
BS02 FMN AD G87 G89 N117 D119 Y205 G208 E209 E210 N245 L428 G57 G59 N87 D89 Y175 G178 E179 E180 N215 L398
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b6f, PDBe:8b6f, PDBj:8b6f
PDBsum8b6f
PubMed36949187
UniProtQ23KE4

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