Structure of PDB 6zsg Chain AD

Receptor sequence

>6zsgAD (length=343) Species: 9606 (Homo sapiens)

SFFTKLTADELWKGALAETGAGAKKGRGKRTKKKKRKDLNRGQIIGEGRY
GFLWPGLNVPLMKNGAVQTIAQRSKEEQEKVEADMIQQREEWDRKKKMKV
KRERGWSGNSWGGISLGPPDPGPCGETYEDFDTRILEVRNVFTMTAKEGR
KKSIRVLVAVGNGKGAAGFSIGKATDRMDAFRKAKNRAVHHLHYIERYED
HTIFHDISLRFKRTHIKMKKQPKGYGLRCHRAIITICRLIGIKDMYAKVS
GSINMLSLTQGLFRGLSRQETHQQLADKKGLHVVEIREECGPLPIVVASP
RGPLRKDPEPEDEVPDVKLDWEDVKTAQGMKRSVWSNLKRAAT

3D structure

• PDB: 6zsg Structural basis of mitochondrial translation.
• Chain: AD
• Resolution: 4.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AD	T91 G101 A104 T106 A108 G109 K111 R114 K116 R117 T118 K119 R191 S194 G195 N196 R226 V228 F229 M231 T232 A233 K234 E235 R242 F256 K260 D266 R269 R297 K299 R300 R315 C316 H317 R318 Y333 A334 V336 S339 I340 N341 L343 W408 W422 R427	T4 G14 A17 T19 A21 G22 K24 R27 K29 R30 T31 K32 R104 S107 G108 N109 R139 V141 F142 M144 T145 A146 K147 E148 R155 F169 K173 D179 R182 R210 K212 R213 R228 C229 H230 R231 Y246 A247 V249 S252 I253 N254 L256 W321 W335 R340
BS02	rna	AD	K112 K120 R189 W198 N227 K239 R264	K25 K33 R102 W111 N140 K152 R177

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zsg, PDBe:6zsg, PDBj:6zsg
• PDBsum: 6zsg
• PubMed: 32812867
• UniProt: P82675|RT05_HUMAN Small ribosomal subunit protein uS5m (Gene Name=MRPS5)