Structure of PDB 8a22 Chain AC

Receptor sequence

>8a22AC (length=139) Species: 353565 (Polytomella magna)

VFAEVKPRQNPQNHTHEKYKIIAPQPKYDWLVGRFIVDRNNVVWHRQANR
NRNRHKKTAGALTRLKRWKPLHKAYAKKLLKLGFKRRFWTDPDPQMVPGF
FDPSKYKPRERLNGKPNLRPDIGCPALRQSQRPLKKLPR

3D structure

• PDB: 8a22 Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements.
• Chain: AC
• Resolution: 2.91 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AC	R73 N75 Q77 H79 K83	R8 N10 Q12 H14 K18
BS02	rna	AC	A88 P89 H137 K143 K146 Q194 S195	A23 P24 H72 K78 K81 Q129 S130
BS03	rna	AC	K142 K146	K77 K81
BS04	rna	AC	Q112 A113 N114 N116 R117 K121 L130 R132 G179 S195 Q196 R197 R204	Q47 A48 N49 N51 R52 K56 L65 R67 G114 S130 Q131 R132 R139
BS05	rna	AC	R117 R119 H120 R174 R176 L183 P185	R52 R54 H55 R109 R111 L118 P120

External links

• PDB: RCSB:8a22, PDBe:8a22, PDBj:8a22
• PDBsum: 8a22
• PubMed: 36253367