Structure of PDB 4ujc Chain AB

Receptor sequence

>4ujcAB (length=611) Species: 9986 (Oryctolagus cuniculus)

DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTG
KTKILDKLRHTHVQDQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLI
IDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCP
FIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQ
QGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRL
AHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
IRGLLLPPPQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPV
LKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGI
NIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFS
AEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKMKILPQYIFNSRDPI
VMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEVNHKQVDVAKKGQEVC
VKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQ
LIVELKKVFEI

3D structure

• PDB: 4ujc Structure of the Mammalian 80S Initiation Complex with Initiation Factor 5B on Hcv-Ires RNA.
• Chain: AB
• Resolution: 9.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	AB	F1316 N1317 S1318 R1319 P1321 I1322 V1323 M1324 G1325 S1354 I1355 E1356 V1371 C1372 V1373 K1374 S1382 P1383 K1384 R1388	F494 N495 S496 R497 P499 I500 V501 M502 G503 S532 I533 E534 V549 C550 V551 K552 S560 P561 K562 R566
BS02	rna	AB	P1321 N1358 Q1361 K1374 R1402	P499 N536 Q539 K552 R580
BS03	rna	AB	P1081 G1082 M1083 G1084 R1116 Q1132 L1148 K1150 E1153 H1228 K1229 K1230 R1254 R1257 D1258	P267 G268 M269 G270 R302 Q310 L326 K328 E331 H406 K407 K408 R432 R435 D436
BS04	GNP	AB	D855 G857 K858 T859 K860 E921 N970 K971 D973 R974 S1038 A1039 H1040	D48 G50 K51 T52 K53 E107 N156 K157 D159 R160 S224 A225 H226

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding

External links

• PDB: RCSB:4ujc, PDBe:4ujc, PDBj:4ujc
• PDBsum: 4ujc
• PubMed: 25064512
• UniProt: G1TRL5