Structure of PDB 6t7n Chain AAAA

Receptor sequence
>6t7nAAAA (length=362) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYF
RGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDI
MDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLK
DLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIY
KRIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQD
DVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEK
DPAKVAVVKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESV
AVVWEKTHKRKK
3D structure
PDB6t7n Trypanosoma cruzi farnesyl diphosphate synthase in complex with IPP and Mn
ChainAAAA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K48 H93 D98 D102 R107 D170 K207 F246 D250 D251
Catalytic site (residue number reindexed from 1) K48 H93 D98 D102 R107 D170 K207 F246 D250 D251
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN AAAA D98 D102 D98 D102
BS02 MN AAAA D98 D102 D98 D102
BS03 IPE AAAA D98 R107 Q167 K207 D250 K264 D98 R107 Q167 K207 D250 K264
BS04 IPE AAAA G47 K48 R51 Q91 R108 F246 D250 G47 K48 R51 Q91 R108 F246 D250
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008299 isoprenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6t7n, PDBe:6t7n, PDBj:6t7n
PDBsum6t7n
PubMed
UniProtQ8WS26

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