Structure of PDB 8vzv Chain AAA

Receptor sequence

>8vzvAAA (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]

GLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILW
ELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTAL
DFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYHYRDNFKGEENEL
LLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRI
QAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQG
ALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKSG
YHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLEH

3D structure

PDB

8vzv Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

AAA

Resolution

2.29 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	AAA	F72 H76 Y79 L132 S151 G152 F153 F158 R159 W324 H328 M331 V332 L351	F34 H38 Y41 L94 S113 G114 F115 F120 R121 W283 H287 M290 V291 L304
BS02	ZIQ	AAA	R103 E105 W208 R211 T212 P213 F304	R65 E67 W167 R170 T171 P172 F263
BS03	A1AER	AAA	F72 H76 R144 L147 A150 S151 L336	F34 H38 R106 L109 A112 S113 L295

External links

PDB	RCSB:8vzv, PDBe:8vzv, PDBj:8vzv
PDBsum	8vzv
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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