Structure of PDB 8pyk Chain AAA

Receptor sequence
>8pykAAA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
VYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTV
NEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRG
DLKSYLRSLRPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED
FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVW
SFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMR
MCWQYNPKMRPSFLEIISSIKEEM
3D structure
PDB8pyk Human IGF1R with inhibitor 47
ChainAAA
Resolution2.23 Å
3D
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IC2 AAA L1005 K1033 M1054 M1079 L1081 M1082 F1131 H1133 M1142 I1151 G1152 D1153 L20 K48 M69 M94 L96 M97 F135 H137 M146 I155 G156 D157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pyk, PDBe:8pyk, PDBj:8pyk
PDBsum8pyk
PubMed
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

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