Structure of PDB 8pdj Chain AAA

Receptor sequence
>8pdjAAA (length=462) Species: 9606 (Homo sapiens) [Search protein sequence]
MEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHD
IYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAK
PEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSG
SEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLP
TWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYR
FERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSD
IMTSDHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQ
TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPE
YLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTG
HFQGEIKLQTSQ
3D structure
PDB8pdj The phosphatase and C2 domains of SHIP1 with covalent Z56948267
ChainAAA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.36: phosphoinositide 5-phosphatase.
3.1.3.56: inositol-polyphosphate 5-phosphatase.
3.1.3.86: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YC5 AAA C505 A563 L564 G565 K567 C111 A169 L170 G171 K173
Gene Ontology
Molecular Function
GO:0016791 phosphatase activity
Biological Process
GO:0046856 phosphatidylinositol dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8pdj, PDBe:8pdj, PDBj:8pdj
PDBsum8pdj
PubMed38309262
UniProtQ92835|SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Gene Name=INPP5D)

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