Structure of PDB 8ohr Chain AAA

Receptor sequence
>8ohrAAA (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
KNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDY
CSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKN
AKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATREDF
LNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLF
KKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNV
TKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPP
LMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
3D structure
PDB8ohr Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B.
ChainAAA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.166: heparanase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VP5 AAA E225 E343 Y348 G349 Q383 Y391 E65 E183 Y188 G189 Q223 Y231
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ohr, PDBe:8ohr, PDBj:8ohr
PDBsum8ohr
PubMed38118176
UniProtQ9Y251|HPSE_HUMAN Heparanase (Gene Name=HPSE)

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