Structure of PDB 8ohq Chain AAA

Receptor sequence
>8ohqAAA (length=385) Species: 9606 (Homo sapiens) [Search protein sequence]
KFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLL
DYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTF
KNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATRE
DFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDT
FAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSL
LFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLH
NVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTL
PPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
3D structure
PDB8ohq Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B.
ChainAAA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.166: heparanase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC AAA H458 K462 H300 K304
BS02 VGO AAA E225 E343 Y348 G349 G350 Q383 Y391 E67 E185 Y190 G191 G192 Q225 Y233
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ohq, PDBe:8ohq, PDBj:8ohq
PDBsum8ohq
PubMed38118176
UniProtQ9Y251|HPSE_HUMAN Heparanase (Gene Name=HPSE)

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