Structure of PDB 8eqe Chain AAA

Receptor sequence
>8eqeAAA (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
YISRYLTDFEPIQCLGRGGGVVFEAKNKVDDCNYAIKRIRLPNRELAREK
VMREVKALAKLEHPGIVRYFNAWLEAPPEKWPKVYLYIQMQLCRKENLKD
WMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRNLKPSNIFFTMD
DVVKVGDFGLVTTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQ
MERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIEN
AVFEDL
3D structure
PDB8eqe Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors.
ChainAAA
Resolution2.559 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WQ2 AAA L599 V607 L643 A644 Y654 I886 M888 C891 F944 D955 F956 L15 V22 L58 A59 Y69 I88 M90 C93 F146 D157 F158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8eqe, PDBe:8eqe, PDBj:8eqe
PDBsum8eqe
PubMed36297668
UniProtQ9NZJ5|E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 (Gene Name=EIF2AK3)

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