Structure of PDB 8eqd Chain AAA

Receptor sequence
>8eqdAAA (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
YISRYLTDFEPIQCLGRGGGVVFEAKNKVDDCNYAIKRIRLPNRELAREK
VMREVKALAKLEHPGIVRYFNAWLEAPPEKWKVYLYIQMQLCRKENLKDW
MNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRNLKPSNIFFTMDD
VVKVGDFGLVTATKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQ
MERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIEN
AVFEDL
3D structure
PDB8eqd Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors.
ChainAAA
Resolution2.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WPX AAA V607 A620 L643 M888 C891 F944 G954 D955 F956 V22 A35 L58 M89 C92 F145 G155 D156 F157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8eqd, PDBe:8eqd, PDBj:8eqd
PDBsum8eqd
PubMed36297668
UniProtQ9NZJ5|E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 (Gene Name=EIF2AK3)

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