Structure of PDB 8dwb Chain AAA

Receptor sequence
>8dwbAAA (length=388) Species: 480019 (Influenza A virus (A/Moscow/10/1999(H3N2))) [Search protein sequence]
AEYRNWSKPQCNITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQ
FALGQGTTLNNGHSNDTVHDRTPYRTLLMNELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCVTGDDENATASFIYNGRLVDSIGSWSKKILRTQESECV
CINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSPLSGSAQHVEECSCY
PRYPGVRCVCRDNWKGSNRPIVDINVKDYSIVSSYVCSGLVGDTPRKNDS
SSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTISEKLRSGYETFKVIE
GWSKPNSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRK
QETEVLWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
3D structure
PDB8dwb Mutational fitness landscape of human influenza H3N2 neuraminidase.
ChainAAA
Resolution1.602 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA AAA R118 E119 D151 R152 A246 E276 R292 R371 Y406 R37 E38 D70 R71 A165 E195 R211 R290 Y325
BS02 CA AAA D293 G297 D324 G345 H347 D212 G216 D243 G264 H266
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dwb, PDBe:8dwb, PDBj:8dwb
PDBsum8dwb
PubMed36640354
UniProtQ8AZ87

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