Structure of PDB 8br7 Chain AAA

Receptor sequence
>8br7AAA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
FHSFSFYELKNVTNNFDERPINKMGEGGFGVVYKGYVNNTTVAVKKLTEE
LKQQFDQEIKVMAKCQHENLVELLGFSDLCLVYVYMPNGSLLDRLSCLDG
TPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISD
FGLARASVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLP
AVDEHREPQLLLDIAAAIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQ
CLHEKKNKRPDIKKVQQLLQEMT
3D structure
PDB8br7 Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 .
ChainAAA
Resolution2.119 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R6R AAA M192 A211 V246 Y262 Y264 M265 P266 G268 T280 L318 M24 A43 V71 Y83 Y85 M86 P87 G89 T101 L139
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8br7, PDBe:8br7, PDBj:8br7
PDBsum8br7
PubMed38228402
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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