Structure of PDB 8bo7 Chain AAA

Receptor sequence
>8bo7AAA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVNYTDSQRPISLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ
3D structure
PDB8bo7 Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.
ChainAAA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QW6 AAA R413 H431 Y521 I528 A570 C571 K572 G573 S575 T593 W595 G596 G598 C599 G606 V607 Y608 R26 H44 Y134 I141 A183 C184 K185 G186 S188 T206 W208 G209 G211 C212 G219 V220 Y221
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8bo7, PDBe:8bo7, PDBj:8bo7
PDBsum8bo7
PubMed37669040
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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