Structure of PDB 8bo4 Chain AAA

Receptor sequence
>8bo4AAA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVNYTDSQRPISLPSVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTN
EECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGI
TSWGEGCAQRERPGVYTNVVEYVDWILEKTQ
3D structure
PDB8bo4 Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.
ChainAAA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QVI AAA L415 C416 H431 Y521 D569 A570 C571 K572 G573 S575 T593 W595 L28 C29 H44 Y129 D177 A178 C179 K180 G181 S183 T201 W203
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8bo4, PDBe:8bo4, PDBj:8bo4
PDBsum8bo4
PubMed37669040
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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