Structure of PDB 8am6 Chain AAA

Receptor sequence

>8am6AAA (length=547) Species: 596154 (Alicycliphilus denitrificans K601) [Search protein sequence]

VLTMTDAQAASASFSAEYDIVVVGSGCAGLTSALFSRWHGNSVVVLEKAA
ALGGTTFKSAFWYWVPNNVPMRAAGIADPKPDFLKYVARVTRPQFYDPEH
PTLGLTQWEYDMCEAIYDSASPAAELLAQKGALPYRHVPFATDFFSELPE
DKAKSGRVLTPKDGSPSMANGGQVAIRTLSTAARRDGIAFKTGHRVQRVI
LNSKGEAIGIEALKDDNSVVRIRARKAVIFGSGGFTHDPELRSNFLNVPV
YGGCAAFTNEGDLVRITSSLGVQLRNMNHAWLCPVTFEKAIGRDGSMSGM
FSVAGDSMIFVDKRGKRVVNEKLNYNELCQKLFEWDGAKVEYPNLVLISI
WDQRSQDHSASNDYGSAIVPPGADDRHVIKSDTLDGLSQQISLRLKKYAG
QIGHMELSSDFNANLRESILRFNGFASTGKDEDFHRGERASDVLFNGSTK
KEPDQKNPTMWPISSVGPYYAALVGGGTLDTKGGPKTNTHGQILDIHDKP
IRGLYGVGNCVASASSGAYWAGGATLGPMIAFAYRAANAAHGEPKRT

3D structure

PDB

8am6 Rational design of cyclohexanone dehydrogenase for enhanced alpha, beta-desaturation and substrate specificity of cyclic ketones

Chain

AAA

Resolution

1.33 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	AAA	V74 G77 A79 E98 K99 G105 T106 T107 S110 A111 W113 V247 S283 G284 C305 T309 N310 D313 S349 F352 L530 N560 G574 T576 L577 M580	V23 G26 A28 E47 K48 G54 T55 T56 S59 A60 W62 V196 S232 G233 C254 T258 N259 D262 S298 F301 L479 N509 G523 T525 L526 M529
BS02	A2Q	AAA	W113 F352 Y376 Y570 G573	W62 F301 Y325 Y519 G522
BS03	A2Q	AAA	E339 R427	E288 R376
BS04	A2Q	AAA	I470 L471 S515 S516	I419 L420 S464 S465
BS05	A2Q	AAA	S353 Y415 L495 F496 G498	S302 Y364 L444 F445 G447

External links

PDB	RCSB:8am6, PDBe:8am6, PDBj:8am6
PDBsum	8am6
PubMed	38550701
UniProt	F4G7N3

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