Structure of PDB 7z4o Chain AAA

Receptor sequence

>7z4oAAA (length=514) Species: 11320 (Influenza A virus)

ERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKE
VNARIEPFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGI
PLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENEE
KIPRTKNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRS
LACWIQSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSH
CRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYG
FIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRT
AVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSV
KEKDLTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYAS
PQLEGFSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLL
NASWFNSFLTHALR

3D structure

• PDB: 7z4o Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
• Chain: AAA
• Resolution: 3.412 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	AAA	A287 L288 K289 L290 T313 R454 L527 M548 L550 V557 R559	A85 L86 K87 L88 T111 R252 L325 M346 L348 V355 R357
BS02	rna	AAA	H326 K328 W368 G371 N373 M374 A375 P376 Y393 S395 P398 R508 H510 R512 V517 N519 K539 R566 T567 N568 G569 K574	H124 K126 W166 G169 N171 M172 A173 P174 Y191 S193 P196 R306 H308 R310 V315 N317 K337 R364 T365 N366 G367 K372

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7z4o, PDBe:7z4o, PDBj:7z4o
• PDBsum: 7z4o
• PubMed: 35605026
• UniProt: M9TI86