Structure of PDB 7u71 Chain AAA

Receptor sequence

>7u71AAA (length=300) Species: 10090 (Mus musculus)

VQFSNASYEAVIMENLALGTEIVRVQAYSNQITYRFDAYTSAQAKALFKI
DAITGVITVKGLVDREKGDFYTLTVVADDGGVDSTVKVYITVLDENDNSP
RFDFTSDSAISVPEDCPVGQRVATVKARDPDAGSNGQVVFSLASGNIAGA
FEIITSNDSIGEVFVAKPLDREELDHYILKVVASDRGTPPRKKDHILQVT
ILDVNDNPPVIESPFGYNVSVNEGGTSVVQVRATDRDIGINSVLSYYITE
GNEDMTFRMDRISGEIATRPARQNFYHLVVTVEDEGTPTLSATTHVYVTI

3D structure

• PDB: 7u71 Crystal Structure of Mouse Cadherin-23 EC13-15
• Chain: AAA
• Resolution: 1.975 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	AAA	E1301 D1355 E1357 D1390	E14 D64 E66 D97
BS02	CA	AAA	E1301 E1357 D1387 E1388 D1390 D1424	E14 E66 D94 E95 D97 D131
BS03	CA	AAA	N1389 N1391 D1422 D1424 N1428 D1478	N96 N98 D129 D131 N135 D185
BS04	CA	AAA	E1407 D1463 E1465 D1499	E114 D170 E172 D206
BS05	CA	AAA	E1407 E1465 D1496 V1497 D1499 D1533	E114 E172 D203 V204 D206 D237
BS06	CA	AAA	N1498 N1500 D1531 D1533 N1537 D1585	N205 N207 D235 D237 N241 D284

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
• GO:0098609 cell-cell adhesion

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7u71, PDBe:7u71, PDBj:7u71
• PDBsum: 7u71
• UniProt: Q99PF4|CAD23_MOUSE Cadherin-23 (Gene Name=Cdh23)