Structure of PDB 7r5x Chain AAA

Receptor sequence
>7r5xAAA (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
SGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKV
CNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAY
IGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCR
VTLGKSFLQFSA
3D structure
PDB7r5x [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
ChainAAA
Resolution2.052 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I6D AAA H1031 G1032 Y1050 Y1060 S1068 Y1071 H81 G82 Y100 Y110 S118 Y121
BS02 ZN AAA C1081 H1084 C1089 C1092 C131 H134 C139 C142
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7r5x, PDBe:7r5x, PDBj:7r5x
PDBsum7r5x
PubMed36598465
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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